Duloxetine and electric shock-like sensations Introduction Duloxetine is a combined serotonin and noradrenalin reuptake inhibitor. It is indicated for the treatment of major depressive disorders, diabetic peripheral neuropathic pain in adults and generalised anxiety disorders

Introduction Duloxetine is a combined serotonin and noradrenalin reuptake inhibitor. It is indicated for the treatment of major depressive disorders, diabetic peripheral neuropathic pain in adults and generalised anxiety disorders [1]. It was granted marketing authorisation in 2004 via a Central European Registration Procedure. Tremor and paraestesia are the most common side effects on the CNS. In the SPC of duloxetine, it is stated that discontinuation of duloxetine, particularly when abrupt, commonly leads to withdrawal symptoms, including sensory disturbances (including paraesthesia). Hence, it is recommended that gradual discontinuation by dose tapering should be carried out [1].